Neuronal Ceroid-Lipofuscinosis 2 (Dachshund)

Application:
- Identification of heterozygous carrier animals.
- Differential diagnosis of diseases of the central nervous system.
The test examines whether the c.325delC mutation, which has been identified as the cause of NCL2 disease, is present in the TTP1 gene. NCL2 (neuronal ceroidipofuscinase 2) is a disease of the central nervous system. Affected animals show perceptual difficulties and increasing motor and cognitive impairments from around 8 months of age. The animals usually do not live beyond 1 year of age. NCL2 is inherited in an autosomal recessive manner, the disease only occurs when two mutated alleles are present.